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Scientific Advisory Board

Charles J. Decedue, Ph. D. trained as a microbiologist, he began his association with the University of Kansas in 1976 as Director of the Biochemical Research Service Laboratory. In 1989, Decedue assumed the position of Executive Director of the Higuchi Biosciences Center. The Higuchi Biosciences Center has the dual mission of enhancing the University’s environment for basic biomedical research and advancing the commercial development of the results of that research. Companies launched from activities of the Higuchi Biosciences Center include Oread Laboratories, Inc., CyDex, Inc., ProQuest Pharmaceuticals, Inc., CritiTech, Inc., BioScience Innovations, Inc., and Admunex, Inc. Decedue has over 30 years experience as a research scientist and administrator.

Valentino J. Stella, Ph. D. is a Distinguished Professor of Pharmaceutical Chemistry at the University of Kansas. His research centers on the application of physical/organic chemistry to the study of factors affecting drug delivery. Dr. Stella is known for his work in improving drug stability and solubility especially as these relate to the preformulation of anticancer and antiAIDS drugs. He also studies the use of prodrugs to overcome problems of solubility and stability and is the inventor of fosphenytoin, a safe injectable form of sodium phenytoin. Current research on prodrugs include the use of prodrugs with greater safety profiles compared to the parent molecules, drug targeting via prodrugs, and novel prodrugs of tertiary amines, hindered alcohols, phenols, imides, and amides. He is also studying the use of novel cyclodextrins that can be used safely in parenteral formulations as well as for oral applications. His work led to the discovery of Captisol™.

Roger A. Rajewski, Ph. D. is currently Director at the Biotechnology Innovation & Optimization Center (BIOC) at the University of Kansas (KU). He has been involved in the Kansas Technology Enterprise Corporation-supported development of University of Kansas technologies for potential commercialization in the private sector. During his tenure at BIOC, Dr. Rajewski has helped guide the development of two additional technologies: drug processing with supercritical fluids and novel prodrug technologies. Multiple patents in both these areas have been or are being secured by the University for CritiTech, Inc., and the prodrug technologies have been licensed to ProQuest Pharmaceuticals, Inc. In addition, BIOC has provided technical input for three Kansas companies not associated with the University. Dr. Rajewski has a Ph.D in Pharmaceutical Chemistry from the University of Kansas.

Bala Subramaniam, Ph. D. is a co-founder of CritiTech. He is currently the Dan F. Servey Distinguished Professor of Chemical and Petroleum Engineering and the Director of the National Science Foundation Engineering Research Center for Environmentally Beneficial Catalysis at the University of Kansas (KU). Dr. Subramaniam obtained a Bachelor's degree in chemical engineering from the University of Madras, India and a Ph. D. degree in chemical engineering from the University of Notre Dame. He joined the KU chemical and petroleum engineering department in 1985, and recently served as chair of his department. He has held visiting Professorships at the Institute of Process Engineering, ETH in Zurich (Switzerland), University of Nottingham (UK) and at the University of California, Davis. Dr. Subramaniam's primary research interests are in catalysis, reaction engineering and crystallization, with emphasis on developing sustainable processes.. In recent years, his research has focused on systematically exploiting the tunable physical and transport properties of CO2-based solvents in developing novel catalytic, particle formation and particle coating processes. He has authored 100+ research publications including 12 patents, presented invited seminars at 70+ universities and companies, and delivered keynote/plenary lectures at 20+ international conferences. Dr. Subramaniam has received several awards for his teaching and research, including the Dow Outstanding Young Faculty Award from the American Society for Engineering Education; the Gould Award for Teaching and the Miller Award for Research from the KU School of Engineering; the Silver Anniversary Teaching Award from the University of Kansas, and a Higuchi Research Achievement Award from KU, the highest recognition for research given by the University of Kansas.

Charles Russell Middaugh, Ph. D. is currently the Aya and Takeru Higuchi Distinguished Professor of Pharmaceutical Chemistry at the University of Kansas. Dr. Middaugh received his Ph.D. in biochemistry from Cornell University in 1978. Before joining the University of Kansas, he was a Senior Scientist for Pharmaceutical Research, Vaccine Division, and Department of Human Genetics at Merck & Co. Previous to his employment with Merck & Co., Dr. Middaugh was a Visiting Scientist at the Massachusetts Institute of Technology, Physics Dept, and a professor at the University of Wyoming for ten years. Dr. Middaugh is currently an Associate Editor (Biotechnology) for the Journal of Pharmaceutical Sciences and on the Editorial Board for the Journal of Biological Chemistry. He also serves as a Faculty Fellow for the Honors Program at the University of Kansas. Dr. Middaugh has received many awards, distinctions, and is often a keynote speaker in the field of biochemistry. So far in 2007, he has over 20 publications, not including patents and abstracts.

David Johnston - (detail coming soon)

 

 

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