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Small Particle
Crystalization Proces:

 

 

The Process:
particle formation
& nanoparticles		 The Process:
coating technology		 Lyophobic
Precipitation		 Advantages of the Technology

Lyophobic Precipitation

  • Alternative to conventional lyophilization
  • Mild processing conditions for biologics
  • Dramatically reduced processing time
  • Reduced particle size/distribution
  • Potential for “single-step” processing & sterilization
  • Potential for significant cost savings in API mfg

 

Process Parameter Conventional Lyophilization CritiTech's CO2-based Technology
Processing Time Days Minutes or Hours
Drying Process Sublimation Solvent extraction
with CO2
Applicability Only water soluble APIs Wide range of APIs
and solvents
including ethanol
Particle Size Broad distribution Easily manipulated;
Uniform distribution

In Situ
Sterilization

 Not possible Possible
Solvent Residue on Product N/A Undetectable
Temperature <0°C 32-40°C

 

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